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KMID : 1145120210190010057
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Asian Journal of Beauty and Cosmetology
2021 Volume.19 No. 1 p.57 ~ p.64
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Anti-aging Effect of Ganoderol A in UVA-irradiated Normal Human Epidermal Keratinocytes
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Shim Joong-Hyun
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Abstract
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Purpose : This research was carried out to investigate the moisturizing effects of Ganoderol A on normal human epidermal keratinocytes (NHEKs).
Methods : The moisturizing effects of Ganoderol A on NHEKs were measured by quantitative real-time RT-PCR to verify the gene expressions related to skin hydration, hyaluronic acid (HA)-enzyme-linked immunosorbent assay (ELISA) to detect HA production, and cell viability assays.
Results : Ganoderol A increased the mRNA levels of the aquaporin 3 (AQP3) and hyaluronan synthase 2 (HAS2) genes and the production of HA in NHEKs. On the other hand, Ganoderol A decreased the mRNA levels of the keratin 1 (KRT1) and keratin 10 (KRT10) genes, which are known as differentiated keratinocyte markers, in NHEKs.
Conclusion : This research showed the moisturizing effects of Ganoderol A. The results indicate that Ganoderol A can be a potent functional ingredient for skin hydration and anti-aging products. Further study is warranted regarding the use of Ganoderol A to develop not only cosmetics but also food and medicine.
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KEYWORD
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Ganoderol A, Hyaluronic acid, AQP3, HAS2, Moisturizing
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